Научно-практический журнал Медицинские технологии. Оценка и выбор
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Issue № 2 | 2015 (20)

Abstract

The article touches upon assessment methodology of treatment compliance, describes existing assessment criteria and gives their sample calculations. Attempt was made to analyze the use of Russian terms for designation of criteria in question.

Keywords

treatment compliance, compliance, treatment adherence duration, continuity of treatment, health technology assessment, period of distribution, acceptable gap.

For citations

Dombrovskiy V.S., Omelyanovskiy V.V. Study Questions of Treatment Compliance: Assessment Criteria and Terminology. Medical Technologies. Assessment and Choice. 2015; 2(20): 16–23.

Issue № 2 | 2015 (20)

Abstract

One of the main goals of a state health care system is improving population health status. It is essential to inform public health policymakers about real problems of citizen health. The authors of Global Burden of Disease study have developed a new approach to compare the effects of different diseases and injuries that lead to premature death and impaired health, and to assess the burden of disease caused by the infl uence of various risk factors. They used Disability-Adjusted Life Years (DALY) indicator to quantify the comparative magnitude of health loss due to different factors. To analyze the major causes of morbidity and premature mortality for the working population in terms of DALYs for Russia in 2013 we used the data, calculations and methodology of GBD study. Also we assessed leading risk factors for illnesses of Russian citizens.

Keywords

GBD research, YLD indicator, YLL indicator, DALY indicator, GDP losses due to disability, risk factors, death and disability causes.

For citations

Skornyakova Е.S. How to Assess Health? Medical Technologies. Assessment and Choice. 2015; 2(20): 9–15.

Issue № 1 | 2015 (19)

Abstract

This paper presents the main elements of the Markov process, including health states, the transition probabilities, cycle tree, and the advantages and disadvantages of both cohort and microsimulation models. Markov models are most often used for the modeling of time-dependent clinical events. The Markov process assumes that patients are always in one of a number of exclusive health states. All events in these models are transitions from one of these states to another. Health technology assessment involves simulating the outcomes of either a cohort or individual patients.

Keywords

Markov process, transition probability, health state, cycle tree, cohort and micro simulations.

For citations

Djalalov S.Ch., Djalalova D.K., Hoch J.S. State-Transition Modeling: Markov Process. Medical Technologies. Assessment and Choice. 2015; 1(19): 18–28.

Issue № 1 | 2015 (19)

Abstract

The questionnaire of the Cochrane Collaboration developed to assess risks of the main bias in randomized controlled trials (RCT) was translated into Russian. It was also adapted and validated. We proposed to consider the risk of the conflict of interests as a mandatory part of the questionnaire. Also we slightly modified the rule to determine the total risk of bias in RCTs. Validation of the questionnaire accomplished by two experts on 20 RCTs demonstrated good agreement: Kappa = 0.785, 95% CI (0.503; 1.000).

Keywords

randomized controlled trials, bias, questionnaire, Cochrane collaboration, validation, adaptation.

For citations

Rebrova O.Yu., Fedyaeva V.K., Khachatryan G.R. Adaptation and Validation of the Cochrane Questionnarie to Assess Risks of Bias in Randomized Controlled Trials. Medical Technologies. Assessment and Choice. 2015; 1(19): 9–17.

Issue № 4 | 2014 (18)

Abstract

This article describes two basic principles of the methodological quality assessment of the original medical research: 1) evaluation of relevance of study design to its objectives, 2) assessment of the methodological quality of studies in aspects of risks of systematic bias and incorrect statistical analysis. This article opens a series of publications that will describe the methods of formalized assessment of methodological quality for each of the most common designs of the original medical research.

Keywords

health technology assessment, evidence, expertise, methodological quality, systematic bias, statistical analysis.

For citations

Rebrova O.Yu. On Principles of Assessment of Medical Research Methodological Quality. Medical Technologies. Assessment and Choice. 2014; 4(18): 15–18.

Issue № 3 | 2014 (17)

Abstract

This article presents a set of current methods applied in personalized medicine including those of molecular genetics, pharmacokinetics, immunological methods and population models. Attention focuses on analytical methods of therapies drug monitoring.

Keywords

personalized medicine, methods, pharmacogenomics, pharmacokinetics, therapies drug monitoring.

For citations

Miroshnichenko I.I., Ptitsina S.N., Simonov A.N. Methodology of Personalized Medicine. Medical Technologies. Assessment and Choice. 2014; 3(17): 18–24.

Issue № 3 | 2014 (17)

Abstract

Economic evaluation is an accepted method for the appraisal of health technologies. This review article aims to provide an introduction to the methodology of the health economic evaluation of a health technology. Attention is paid to defining the fundamental concepts and terms related to health technology assessment, health economics and pharmacoeconomics. The article describes the methodology underlining health outcomes and costs, pros and cons of different types of economic studies and a review of economic evaluation methods. Key references are provided for those who wish for a more advance understanding of health economic assessment.

Keywords

health economics, health technology assessment, outcomes, cost, economic evaluation methods and types of economic studies.

For citations

Djalalov S.Ch., Djalalova D.K., Hoch J.S. Introduction to Economic Evaluation of Health Technologies. Medical Technologies. Assessment and Choice. 2014; 3(17): 10–17.

Issue № 2 | 2014 (16)

Abstract

The article briefly reviews the modern view of early health technology assessment (HTA), including its role for national and private investment in the development of new technologies. This approach appears to be comparatively novel for most countries, and in the author’s opinion it should be implemented when the 2020 program for the development of medical and pharmaceutical industry is realized in Russia. One of the practical objectives of this review is to inform the experts responsible for making key decisions about the methods which can be used at early stages of the assessment of new products and technologies, as well as to explore the avenues for further methodological improvements in this emerging branch of HTA.

Keywords

health technology assessment, early health technology assessment, return on investment, investment appeal.

For citations

Omelyanovsky V.V. Early Health Technology Assessment as a Tool for Evaluating and Steering the Creation of New Medical Products. Medical Technologies. Assessment and Choice. 2014; 2(16): 23–29.

Issue № 2 | 2014 (16)

Abstract

The development of model for use in health technology assessment begins with an understanding of the clinical problem and basic concept of the research question. The goal of this paper is to introduce best practices for model conceptualization. The conceptualization process has two separate components: 1) the conceptualization of the problem and 2) the conceptualization of the model. Recommendations are made regarding the statement of the clinical problem, perspective and target population of the model, selection of comparators, time horizon, valuing outcomes, unit of representation, interaction between individuals and other model components.

Keywords

modeling, conceptualization, methods, state-transition model, discrete event simulation dynamic transition model.

For citations

Djalalov S.Ch., Djalalova D.K., Hoch J.S. Model Conceptialization in Health Technology Assessment. Medical Technologies. Assessment and Choice. 2014; 2(16): 16–22.