Issue № 31 | 2018 (1)
Transdermal drug delivery – a method that is used to deliver the drug into the systemic circulation through the skin. This mechanism of drug delivery has many advantages, including the achievement of a stable plasma concentrations, improved patient compliance to the dosage form of this, elimination of first pass through the liver damage in the absence of the gastrointestinal tract. Over the past 30 years has been put on the market a lot of drugs having transdermal structure. Despite the inherent benefits of a transdermal therapeutic system (TTS) and a growing list of products, one of the main drawbacks is the appearance of TTC inter-and intraindividual difference in absorption of the drug through the skin. The reason most of these differences is the number of biological factors such as gender, age, ethnicity and skin hydration and metabolism. These factors affect the integrity and barrier properties of the skin, which can then lead to a change in the amount of absorption of the drug. The main purpose of this review article is to provide a brief commentary on the biological factors that contribute to the change in the penetration of drugs as part of TTC through human skin.
transdermal therapeutic system, differences in skin absorption, biological factors.
Tarasov V. V., Sologova S. S., Musina N. Z., Chubarev V. N., Schakhmardanova S. A., Grigorevskikh E. M., Preferanskay N. G., Zatsepilova T .A., Sologova D. I. Influence of Biological Factors on Transdermal Drug Delivery System. Medical Technologies. Assessment and Choice. 2018; 1(31): 95–101.